Embed from Getty ImagesCardiff City have signed defender Ciaron Brown from Wealdstone.The 20-year-old, who previously had a trial with Sheffield Wednesday, made 66 appearances for the Stones after being signed from Bedfont Sports.“I’d like to wish Ciaron a very successful career,” said Stones boss Bobby Wilkinson.“It’s a great achievement to become a pro. He’s worked very hard and we will always support him and we will follow his progress with great interest.”Cardiff will visit Wealdstone in a pre-season friendly this summer as part of the deal agreed between the two clubs.See also:Stones defender to join Sheffield Wednesday on trialShrewsbury sign Eisa from WealdstoneStones complete signing of striker BubbWealdstone bring in Reading defender on loan Follow West London Sport on TwitterFind us on Facebook
Colin Kaepernick can’t even get an invite from an NFL team, but could the former 49ers quarterback somehow find his way onto a Pro Bowl roster?That may be a stretch, but it won’t be for a lack of effort on the part of Kaepernick supporters on Twitter.The NFL is inviting fans to cast their votes via Twitter and Kap’s camp is making a push to get the free agent to Orlando for the Pro Bowl on Jan. 28.Unlike the NFL’s official ballot, fans can cast a vote for players on Twitter who aren’t listed …
We’ve explained elsewhere about the family of molecular machines called aminoacyl-tRNA synthetases (see 05/26/2004 entry and its embedded links). Their job is to associate each word of DNA code (codon) with its corresponding piece of a protein (amino acid). In a very real sense, they translate the DNA code into the protein code. One amazing capability of these machines is that they proofread their work. They can differentiate between similar molecules, and edit out incorrect pieces inserted by mistake. Scientists from Scripps Institute writing in PNAS1 thought they would watch what happened when they gave one of these translators a mutation that diminished this editing ability. It wasn’t pretty:The genetic code is established in aminoacylation reactions catalyzed by aminoacyl-tRNA synthetases. Many aminoacyl-tRNA synthetases require an additional domain for editing, to correct errors made by the catalytic domain. A nonfunctional editing domain results in an ambiguous genetic code, where a single codon is not translated as a specific amino acid but rather as a statistical distribution of amino acids. Here, wide-ranging consequences of genetic code ambiguity in Escherichia coli were investigated with an editing-defective isoleucyl-tRNA synthetase. Ambiguity retarded cell growth at most temperatures in rich and minimal media. These growth rate differences were seen regardless of the carbon source. Inclusion of an amino acid analogue that is misactivated (and not cleared) diminished growth rate by up to 100-fold relative to an isogenic strain with normal editing function. Experiments with target-specific antibiotics for ribosomes, DNA replication, and cell wall biosynthesis, in conjunction with measurements of mutation frequencies, were consistent with global changes in protein function caused by errors of translation and not editing-induced mutational errors. Thus, a single defective editing domain caused translationally generated global effects on protein functions that, in turn, provide powerful selective pressures for maintenance of editing by aminoacyl-tRNA synthetases. (Emphasis added.)In short, removing the editing created big problems. The poor bacteria were stunted and vulnerable to malfunctions. When the translator could not maintain high fidelity by editing out mistakes, crippled proteins were produced, and the organism became a sitting duck for the harsh realities of survival.Update 01/26/2005: This paper generated a commentary in PNAS by Randall Hughes and Andrew Ellington of the University of Texas.2 They agreed that “over the long run, there has been and will continue to be tremendous selective pressure to maintain the current genetic code.” But they surmise that, since not all the substituted amino acids produced fatalities, evolution might take advantage of them. “Taking advantage of protein misfolding might at first seem to be an improbable event,” they admit, “but this phenomenon is conceptually similar to other ways in which organisms take evolutionary advantage of even inclement environments.” Like citizens under siege scrounging for food, they envision a cell under stress with “a general need to explore a larger genetic space or a larger protein folding space or both.” Maybe the cell has already planned for such things through experience. “To the extent that organisms have encountered environmental stress intermittently over evolutionary time,” they write, “it may even be advantageous to establish some sort of regulatory feedback between stress and phenotypic exploration.” In the end, though, they agree that the cell works hard to prevent such errors and possesses exquisite means to eliminate typos. That means it will be difficult to find ways to change the genetic code in lab organisms: “simple substitutions will be an uphill battle.”1Bacher, Crécy-Lagard and Schimmel, “Inhibited cell growth and protein functional changes from an editing-defective tRNA synthetase,” Proceedings of the National Academy of Sciences USA, 10.1073/pnas.0409064102, published online before print January 12, 2005.2Randall A. Hughes and Andrew D. Ellington, “Mistakes in translation don’t translate into termination,” Proceedings of the National Academy of Sciences USA, February 1, 2005, vol. 102, no. 5, pp. 1273-1274.Notice that they implied that natural selection had strong motivation to preserve the editing function of these machines. They did not say natural selection had the ability to originate these machines. That supports creation, not evolution. Hughes and Ellington added nothing but speculation: namely, the Darwinian plot line that stress is good, because it forces organisms to evolve or perish. But they only gave examples of mechanisms that are already in place to respond to stress. They did not show how a mindless cell would think to itself, “Y’know, I really ought to come up with a disaster plan.”(Visited 11 times, 1 visits today)FacebookTwitterPinterestSave分享0
Share Facebook Twitter Google + LinkedIn Pinterest Led by weak crop prices and exacerbated by a sharp decline in livestock prices, particularly cattle, net farm income dropped significantly in 2015, a Federal Reserve Bank economist said. In fact, farm income has dropped by 55% since 2013, said Nathan Kauffman, an economist who also serves as assistant vice president and Omaha Branch executive with the Federal Reserve Bank of Kansas City. Kauffman addressed farmers and ranchers from across the U.S. during a workshop on trends in farm income and land values at the American Farm Bureau Federation’s 97th Annual Convention.“I don’t have the best of news to share this morning,” Kauffman said. The “sky is not falling,” he added, “but this is definitely a period of adjustment.”However, he said that the drop in income has so far not been accompanied by a drop in farmland values.“Farmland values have, in many ways, defied expectations associated with lower crop values,” he said.Among the factors that are driving the decrease in crop prices is a gradual buildup in the global supply of all major commodities, including corn, soybeans and wheat.“Global inventory is very, very high,” he said.At the same time, key demand factors have also “softened significantly,” he said, specifically mentioning ethanol production, which has been nearly flat in the past few years, and U.S. exports to China, which have decreased steadily as growth has slowed in that market.An additional factor is credit conditions, which have deteriorated in the past two or three years. A strong dollar, coupled with a somewhat sluggish global economy, has made selling crops overseas more difficult, he added.Despite all these negatives, farmland values have remained relatively steady.“The changes in crop values haven’t been met with changes in land prices,” he said.One of the major reasons is that there just hasn’t been a lot of land on the market. In addition, he noted that how land prices fare depends very much on the quality of the land.“It’s not across the board,” he said. “Very-high quality land is fetching very good prices,” but more marginal land is seeing some decreases. He added that while land prices have increased faster than rents, both have been slow to adjust to the decreases in crop prices.“It’s not what you would have expected when corn drops from $6 (per bushel) to $3,” he said.
By Jen Pearce, Geocaching HQ EmployeeHave you been to Seattle, home of Geocaching HQ, in the winter time? It rains here — a LOT and we just had our wettest winter on record. Many Seattleites try to visit sunnier climates during this season, and the employees at HQ are no different. So where to?Factoring in our limited time (a weekend), our shared interest (geocaching), and our greatest desire (to see the sun), we decided to go to Las Vegas, Nevada!Our first stop was Route 66, a historic highway that runs from Chicago, IL to Santa Monica, CA. The highway fell out of use in the 80s when the Interstate Highway System was created, leaving behind ample, rarely-disturbed space for geocaches.“Bruning” (made popular by one of our beloved Portuguese reviewers).Our next stop was Hofbräuhaus Beer Hall for GC6BJG6, an Event Cache to meet up with local and visiting geocachers in Las Vegas.Group shot! Not pictured: The 4 Musketeers (composed of Huntersam, Necrolink, Cedestelle, and Comètes) who came all the way from France.Our last stop was the Valley of Fire, Nevada’s oldest and largest state park.The park is home to petroglyphs, gorgeous red sandstone ranges, EarthCaches, and the final resting place of Captain Kirk from the movie Star Trek: Generations.The peak seen in the movie is called Silica Dome, which also happens to host GC4Z3F6: an EarthCache by Landondena. There is an “easy” way to reach the dome and a “hard” way — we took the hard way.Other notable EarthCaches (and a Virtual!) we found within the park: GC1PPNP, GC1PPNG, GCH723 (limited time meant leaving the park before we found all of the caches).Moun10BikeThe next time you venture through Nevada, keep an eye out for the Lackeys on Tour stamp in the local logs.HQ’ers were here.Until next time…Left to right: itschautime, Heather Feather, Love, oceansazul, catfax, Moun10Bike, and Sassy BanditShare with your Friends:More SharePrint Related116 Geocaches an Hour and AliensNovember 1, 2013In “Community”Geocaching adventures in New MexicoApril 26, 2018In “Community”Dear Geocaching Diary: Orange Headbands for the WinSeptember 1, 2013In “Community”
by Karen Shirer, Ph.DSeveral years ago, a colleague hired six new educators to work on an emerging public health issue. All six hires were “millennials,” individuals born between 1981 and 1995. They were the first millennials that had been hired into his organizations.Needless to say, my colleague experienced rising tensions between the millennials and the baby boomers (born between 1946 and 1964) who had worked a long time in the organization. Neither generational group was prepared to work with the other in a team environment. Nor was my colleague prepared to address the conflicts and tensions that arose. In the end, most of the newly hired educators left the organization and an educator of the baby boomer generation lodged an age discrimination complaint.I thought of my colleague as I viewed Part II of the webinar Engaging Across Generations Part II: Tools and Techniques. This blog post describes the key lessons I learned that would have benefited my colleague as a boomer bringing on the first millennial hires. Recently, a blog on Part I of the Engaging Across Generations: Unique Mindsets webinar was published and you can view both the webinar and read the blog. Facilitators for both webinars were University of Minnesota Extension Educators Lisa Hinz and Brian Fredrickson. .The United States currently has five generations that make up adulthood and can be found in families, workplaces and communities. Before talking about what I learned about engaging across two generations, here is a recap of all five.Traditionalists were born before 1946 and are now 72 years and older.Boomers were born between 1946 and 1964, and are ages 53 to 71 years of age now (this is where my colleague resides)GenXers were born from 1965 through 1980, and are currently ages 37 to 52 years.GenY or Millennials were born between 1981 and 1995, and are currently aged 22 to 36 years (the approximate ages of my colleague’s new employees)GenZ individuals were born after 1996, with the older folks currently 21 years of age.So, what were the five lessons I learned from the Engaging Across Generations Part II: Tools and Techniques webinar that would have helped my colleague as he brought on six new educators of the millennial generation into a current group of educators from the boomer generation?Lesson #1: Know and Appreciate the Strengths of Each GenerationMillennials make up one-third of the US population. They tend to be civically engaged, tech-able, hopeful, carefully weigh all the options when making decisions, and value collective action. They hold a strong team ethic, a value for collective action and an openness to adaptation.Boomers have political leverage and clout, and are good networkers. They value equality, hard work, being team players, and challenging the status quo. Throughout their lives, boomers possessed a drive to learn and become self-actualized.Both of these lists show that there are commonalities but also differences. These differences can be leveraged. Recently, I began using social media, which for millennials is second nature, and my millennial colleagues were very helpful. As a boomer, I love to network and quickly learned that social media is the new networking. If my colleague knew each group’s strengths, he might have been better able to leverage them to develop the work team.Lesson #2: Understand the tensions that could occurResearch shows that 2/3rds of things with which we disagree with another on are things that we will never agree on. So it helps to understand that disagreement and conflict are normal between co-workers and in teams. Look for where there is agreement and show respect for differences of values and viewpoints.There are larger societal tensions looming between these two generations due to major demographic shifts. For example, millennials will bear the burden of supporting the safety net for boomers as they retire and grow older. Right now, these tensions are not as evident but they will come and as a society, we all need to prepare for them now.Lesson #3: Strengthen your communication skillsWith the respect garnered in the second lesson, honing one’s communication skills would be very helpful. Some key tips include: ask questions, don’t assume or tell; use multiple communication avenues, including social media; and don’t take things personally. Even more important, think carefully about the other person and tailor the message to him or her. Consider what factors motivate him or her while at the same time be open to learning from the other person and to teaching the other person.Lesson #4: Promote reciprocal mentoringReciprocal mentoring basically means setting up a mentoring relationship where the millennial is mentoring the boomer (like my social media experience) and the boomer mentors the millennial. The focus of mentoring varies based on each other’s strengths.Some advice for millennials mentoring boomers involves being tactful, listening and not blaming, showing warmth, and letting the boomer talk about their work and experiences. Boomers need to listen, give structure, be an advocate, and share themselves with millennials.Lesson #5: Be humble and open to changeOne area that boomers report problems is when millennials do not value their experience and work. As expected, this can be rich ground for conflict. With my boomer status, I have often cringed when a millennial “schools” me on how to do certain things for which I had done a large amount of work. I’ve learned to bite my tongue, ask questions, listen and encourage. I need a good dose of humility to remember that I do not have it all figured out and neither do my millennial colleagues.Do you want to learn more? Here are three steps you can take today:1. View Part II of the webinar, Engaging across Generations, titled “Tools and Techniques.”2. Learn more about reciprocal mentoring with L. D. Parks book, Mentor: Guiding the Journey of Adult Learners. Chapter 8, The Yoda Factor, describes the process.3. Participate in the October 31, 2017 webinar sponsored by MFLN Family Transitions & Personal Finance on Financial Planning for Different Generations: Touchstones, Tasks & Teaching Strategies.If you haven’t done so already, view Part 1 of the Engaging Across Generations: Unique Mindsets webinar , review the resources highlighted in the webinar, including Jennifer Deal’s book, and read my blog about the Generations I webinar. Note, additional webinar handouts (Generations: Who Are They? and Engaging Across Generations Part I) are located on the webinar event page under the “Event Materials” located at the bottom of the page.Karen Shirer is a member of the Military Families Learning Network Family Transitions Team and the Associate Dean with the University of Minnesota, Extension Center for Family Development. Karen is also the parent of two adult daughters, a grandmother, a spouse, and a cancer survivor.
You cannot serve two masters, but you pay attention to the second master if you are an operator. The need to sell and market isn’t diminished by your need to run the operation.
Although he came up short against one of the best boxers to ever lace up a pair of gloves, Conor McGregor was widely praised by the mixed martial arts (MMA) community for his valiant effort against Floyd Mayweather Jr. last week.FEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSPrivate companies step in to help SEA Games hostingSPORTSBoxers Pacquiao, Petecio torchbearers for SEA Games openingBut not everyone was pleased with the Irish superstar’s crossover from the octagon to the boxing ring, especially his rival Nate Diaz, who chastised the UFC Lightweight Champion in a recent social media post.ADVERTISEMENT Ethel Booba on hotel’s clarification that ‘kikiam’ is ‘chicken sausage’: ‘Kung di pa pansinin, baka isipin nila ok lang’ Hotel says PH coach apologized for ‘kikiam for breakfast’ claim Robredo should’ve resigned as drug czar after lack of trust issue – Panelo MOST READ NATO’s aging eye in the sky to get a last overhaul Houston Rockets sold for $2.2 billion Trump signs bills in support of Hong Kong protesters LATEST STORIES Diaz won their first bout via rear-naked choke, while McGregor avenged that loss at UFC 202 via decision. /raRELATED STORIES:UFC: Trilogy bout with Nate Diaz should happen at 155 lbs, McGregor insistsUFC: Diaz not rushing McGregor trilogy, says he won both fightsSports Related Videospowered by AdSparcRead Next Robredo: True leaders perform well despite having ‘uninspiring’ boss PLAY LIST 02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games Don’t miss out on the latest news and information. Lacson: SEA Games fund put in foundation like ‘Napoles case’ The 32-year-old lanky fighter reposted a photo from the UFC’s official Instagram page, which quoted McGregor as saying, “I Never Lose Either I Win Or I Learn.” Celebrity chef Gary Rhodes dies at 59 with wife by his side In true Diaz fashion, he lashed out at his former adversary and described the “fight of the century” as “over promotion.”“He punched himself out the same way he lost in the Ufc there was no learning goin on..,” he wrote.“Bullsh** get off the nuts this the sh*t I’m talking about Bruce Lee would’ve never lost like that,” he added, along with another expletive hashtag and emoji.Diaz’s comments came after McGregor appeared to be winning the early rounds of the bout, before Mayweather picked up his rhythm en route to a TKO victory in the 10th round. The MMA fighter was visibly gassed mid-way to the fight—which Diaz knows all too well as McGregor’s cardio was also suspect the first time they fought at UFC 196 last year.Although Diaz’s smack talk is nothing new for MMA fans, it certainly sets up the stage for a a possible trilogy bout, when McGregor decides to return to the promotion.ADVERTISEMENT Celebrity chef Gary Rhodes dies at 59 with wife by his side View comments
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Lacson backs proposal to elect president and vice president in tandem View comments That’s bad news from the rest of the field.Stephanie Niemer scored 23 points, while a flu-stricken Kath Bell added 19 for Petron, which finished the job in just 66 minutes.Niemer, who is hunting her first PSL crown, unloaded 18 kills, one block and four aces.“It’s really proud of our imports, they’re very dedicated and very professional,” said Delos Santos.Erica Wilson provided 13 points for the HD Spikers, who fell to 4-3.ADVERTISEMENT PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss The Blaze Spikers will start their second round campaign when they battle struggling Foton on Tuesday at the Filoil Flying V Centre.Meanwhile, Lindsay Stalzer led the Cargo Movers with 19 points as they moved up to 6-1, while PLDT fell to 3-4. —MARC ANTHONY REYESSports Related Videospowered by AdSparcRead Next The two parted ways last Thursday after sharing the tournament lead for quite some time—Petron pinned a first loss on F2 Logistics—but except for their slightly different records, they’re back to doing the same old stuff.Whipping their PSL foes.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSUrgent reply from Philippine football chiefSPORTSPalace wants Cayetano’s PHISGOC Foundation probed over corruption chargesIt was a clean sweep of the their first seven matches for the Blaze Spikers, who appear to be peerless at this point of the conference.“I think we did a good job, but it doesn’t end here,” said Petron coach Shaq Delos Santos. “It’s a good thing if we can maintain our winning streak. But we still have to step up if we want to remain undefeated in this very tough tournament.” Don’t miss out on the latest news and information. P2.5 B shabu seized in Makati sting, Chinese national nabbed P2.5 B shabu seized in Makati sting, Chinese national nabbed Hong Kong tunnel reopens, campus siege nears end Make it a ‘5-peat’ for CEU MOST READ LATEST STORIES SEA Games hosting troubles anger Duterte Photo by Tristan Tamayo/INQUIRER.netPetron fittingly closed out the first round by dominating Cignal, 25-15, 25-19, 25-14, Saturday night in the Philippine Superliga Grand Prix at Muntinlupa Sports Center.F2 Logistics bounced back from a loss after crushing PLDT, 25-20, 25-21, 25-19 in the other game.ADVERTISEMENT Trump campaign, GOP groups attack Google’s new ad policy 1 dead, 3 injured in Quezon road crash Private companies step in to help SEA Games hosting